[HTML][HTML] Localization of low density lipoprotein receptor-related protein 1 to caveolae in 3T3-L1 adipocytes in response to insulin treatment
H Zhang, PH Links, JK Ngsee, K Tran, Z Cui… - Journal of Biological …, 2004 - ASBMB
The insulin-induced translocation of low density lipoprotein receptor-related protein 1
(LRP1) from intracellular membranes to the cell surface in 3T3-L1 adipocytes was
differentiation-dependent and did not occur in 3T3-L1 fibroblasts. Prompted by findings that
the plasma membrane of 3T3-L1 adipocytes was rich in caveolae, we determined whether
LRP1 became caveolae-associated upon insulin stimulation. The caveolae domain was
isolated by the well characterized detergent solubilization and sucrose density …
(LRP1) from intracellular membranes to the cell surface in 3T3-L1 adipocytes was
differentiation-dependent and did not occur in 3T3-L1 fibroblasts. Prompted by findings that
the plasma membrane of 3T3-L1 adipocytes was rich in caveolae, we determined whether
LRP1 became caveolae-associated upon insulin stimulation. The caveolae domain was
isolated by the well characterized detergent solubilization and sucrose density …