Astroglial overproduction of TGF-β1 enhances inflammatory central nervous system disease in transgenic mice
T Wyss-Coray, P Borrow, MJ Brooker… - Journal of …, 1997 - Elsevier
Cerebral expression of the injury response cytokine transforming growth factor-β1 (TGF-β1)
has been found to be increased in several neurological diseases but it remains unclear
whether its function is primarily beneficial or detrimental. Here we show that transgenic (tg)
mice that overexpress bioactive TGF-β1 in the central nervous system (CNS) and show no
overt phenotype in the unmanipulated state, are more susceptible to the immune-mediated
CNS disease experimental autoimmune encephalomyelitis (EAE). TGF-β1 tg mice with EAE …
has been found to be increased in several neurological diseases but it remains unclear
whether its function is primarily beneficial or detrimental. Here we show that transgenic (tg)
mice that overexpress bioactive TGF-β1 in the central nervous system (CNS) and show no
overt phenotype in the unmanipulated state, are more susceptible to the immune-mediated
CNS disease experimental autoimmune encephalomyelitis (EAE). TGF-β1 tg mice with EAE …