WE HAVE BEEN CLOSET CARTESIANS IN MODERN medicine, treating the mind as
though it were reactive to but otherwise disconnected from disease in the body. Although
medical science has productively focused on the pathophysiology of disease, such as tumor
biology, coronary artery disease, and immunology, it has done so at the expense of studying
the body's psychophysiological reactions to these disease processes. These reactions are
mediated by brain and body mechanisms, including the endocrine, neuroimmune, and …