Exogenous lipids influence permeability barrier recovery in acetone-treated murine skin

MQ Man, KR Feingold, PM Elias - Archives of dermatology, 1993 - jamanetwork.com
• Background and Design.—When the epidermal permeability barrier is perturbed with
acetone, transcutaneous water loss returns to normal over 24 hours in parallel with the
reappearance of stratum corneum lipids, derived from secreted lamellar bodies and
accelerated lipid synthesis. Prior studies have demonstrated a separate requirement for
cholesterol, fatty acid, and ceramide synthesis for barrier homeostasis, but the requirement
for these lipids individually or together for barrier function is not known. We therefore applied …