Coordinate assembly of lipids and enzyme proteins into epidermal lamellar bodies
U Rassner, KR Feingold, DA Crumrine, PM Elias - Tissue and Cell, 1999 - Elsevier
Formation of the epidermal permeability barrier requires delivery of lamellar body (LB)
contents to the stratum corneum interstices. LB are enriched in a mixture of polar lipids and a
family of hydrolytic enzymes, required for the extracellular processing of the secreted polar
lipids into the more hydrophobic products which mediate barrier function. Prior non-
quantitative studies show that acute barrier disruption leads to immediate secretion of the
contents of performed LB from the outermost layer of granular cells, followed by the …
contents to the stratum corneum interstices. LB are enriched in a mixture of polar lipids and a
family of hydrolytic enzymes, required for the extracellular processing of the secreted polar
lipids into the more hydrophobic products which mediate barrier function. Prior non-
quantitative studies show that acute barrier disruption leads to immediate secretion of the
contents of performed LB from the outermost layer of granular cells, followed by the …