[HTML][HTML] Insulin-degrading enzyme regulates extracellular levels of amyloid β-protein by degradation
WQ Qiu, DM Walsh, Z Ye, K Vekrellis, J Zhang… - Journal of Biological …, 1998 - ASBMB
Excessive cerebral accumulation of the 42-residue amyloid β-protein (Aβ) is an early and
invariant step in the pathogenesis of Alzheimer's disease. Many studies have examined the
cellular production of Aβ from its membrane-bound precursor, including the role of the
presenilin proteins therein, but almost nothing is known about how Aβ is degraded and
cleared following its secretion. We previously screened neuronal and nonneuronal cell lines
for the production of proteases capable of degrading naturally secreted Aβ under …
invariant step in the pathogenesis of Alzheimer's disease. Many studies have examined the
cellular production of Aβ from its membrane-bound precursor, including the role of the
presenilin proteins therein, but almost nothing is known about how Aβ is degraded and
cleared following its secretion. We previously screened neuronal and nonneuronal cell lines
for the production of proteases capable of degrading naturally secreted Aβ under …