The Furin Inhibitor Hexa-d-Arginine Blocks the Activation of Pseudomonas aeruginosa Exotoxin A In Vivo
MS Sarac, A Cameron, I Lindberg - Infection and immunity, 2002 - Am Soc Microbiol
MS Sarac, A Cameron, I Lindberg
Infection and immunity, 2002•Am Soc MicrobiolThe Pseudomonas aeruginosa exotoxin A (PEA) protein requires furin-mediated cleavage
for manifestation of toxicity. We show here that the small stable furin inhibitor hexa-d-
arginine amide effectively blocks PEA-induced cell lysis and is itself noncytotoxic.
Administration of hexa-d-arginine to PEA-treated mice significantly improves their survival
rate and also decreases circulating levels of tumor necrosis factor alpha.
for manifestation of toxicity. We show here that the small stable furin inhibitor hexa-d-
arginine amide effectively blocks PEA-induced cell lysis and is itself noncytotoxic.
Administration of hexa-d-arginine to PEA-treated mice significantly improves their survival
rate and also decreases circulating levels of tumor necrosis factor alpha.
Abstract
The Pseudomonas aeruginosa exotoxin A (PEA) protein requires furin-mediated cleavage for manifestation of toxicity. We show here that the small stable furin inhibitor hexa-d-arginine amide effectively blocks PEA-induced cell lysis and is itself noncytotoxic. Administration of hexa-d-arginine to PEA-treated mice significantly improves their survival rate and also decreases circulating levels of tumor necrosis factor alpha.
American Society for Microbiology