Nuclear β-catenin expression distinguishes deep fibromatosis from other benign and malignant fibroblastic and myofibroblastic lesions
B Bhattacharya, HP Dilworth… - The American journal …, 2005 - journals.lww.com
Deep fibromatoses (desmoid tumors) are clonal myofibroblastic proliferations that are prone
to aggressive local recurrences but that do not metastasize. They must be distinguished from
a host of fibroblastic and myofibroblastic lesions as well as from smooth muscle neoplasms.
Virtually all deep fibromatoses have somatic β-catenin or adenomatous polyposis coli (APC)
gene mutations leading to intranuclear accumulation of β-catenin. Since low-grade
sarcomas in general lack β-catenin and since reactive proliferations would not be expected …
to aggressive local recurrences but that do not metastasize. They must be distinguished from
a host of fibroblastic and myofibroblastic lesions as well as from smooth muscle neoplasms.
Virtually all deep fibromatoses have somatic β-catenin or adenomatous polyposis coli (APC)
gene mutations leading to intranuclear accumulation of β-catenin. Since low-grade
sarcomas in general lack β-catenin and since reactive proliferations would not be expected …