Secretion of extracellular proteins by enterohemorrhagic Escherichia coli via a putative type III secretion system

KG Jarvis, JB Kaper - Infection and immunity, 1996 - Am Soc Microbiol
KG Jarvis, JB Kaper
Infection and immunity, 1996Am Soc Microbiol
Enterohemorrhagic and enteropathogenic Escherichia coli (EHEC and EPEC) infections
result in attaching and effacing lesions on intestinal epithelial cells. Secretion of extracellular
proteins via a type III secretion apparatus is necessary for the formation of attaching and
effacing lesions by EPEC. We now show that EHEC also secretes polypeptides via a
putative type III secretion system. The secreted EHEC proteins are recognized by rabbit
antiserum raised against the proteins secreted from EPEC and by human serum from a …
Enterohemorrhagic and enteropathogenic Escherichia coli (EHEC and EPEC) infections result in attaching and effacing lesions on intestinal epithelial cells. Secretion of extracellular proteins via a type III secretion apparatus is necessary for the formation of attaching and effacing lesions by EPEC. We now show that EHEC also secretes polypeptides via a putative type III secretion system. The secreted EHEC proteins are recognized by rabbit antiserum raised against the proteins secreted from EPEC and by human serum from a patient infected with an EHEC O157:H7 strain.
American Society for Microbiology