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Improving CAR T cell immunotherapy–mediated remissions for pediatric leukemia
David M. Barrett
David M. Barrett
Published April 15, 2019
Citation Information: J Clin Invest. 2019;129(5):1842-1844. https://doi.org/10.1172/JCI128743.
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Commentary

Improving CAR T cell immunotherapy–mediated remissions for pediatric leukemia

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Abstract

Chimeric antigen receptor (CAR) T cells are an effective therapy for relapsed or refractory pediatric B cell leukemia. Analysis of the starting material, the T cells collected from the patient prior to CAR manufacture, reveals possible biomarkers of cells destined to perform poorly in patients. Long-term follow-up shows that long periods of B cell aplasia, a marker of in vivo CAR activity, are associated with longer remission but also a higher chance of antigen-negative relapse. The role of transplantation as consolidative therapy is unclear in this nonrandomized data, but clearly warrants further study.

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David M. Barrett

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