Phospholipid signaling in innate immune cells
Valerie B. O’Donnell,1 Jamie Rossjohn,1,2,3 and Michael J.O. Wakelam4
1Systems Immunity Research Institute and Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, United Kingdom.
2Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, and
3ARC Centre of Excellence in Advanced Molecular Imaging, Monash University, Clayton, Victoria, Australia.
4Babraham Institute, Babraham Research Campus, Cambridge, United Kingdom.
Address correspondence to: Valerie B. O’Donnell, Systems Immunity Research Institute, Cardiff University, Heath Park, Cardiff, CF14 4XN, United Kingdom. Phone: 44.2920.687313; Email: o-donnellvb@cardiff.ac.uk.
Find articles by O’Donnell, V. in: JCI | PubMed | Google Scholar
1Systems Immunity Research Institute and Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, United Kingdom.
2Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, and
3ARC Centre of Excellence in Advanced Molecular Imaging, Monash University, Clayton, Victoria, Australia.
4Babraham Institute, Babraham Research Campus, Cambridge, United Kingdom.
Address correspondence to: Valerie B. O’Donnell, Systems Immunity Research Institute, Cardiff University, Heath Park, Cardiff, CF14 4XN, United Kingdom. Phone: 44.2920.687313; Email: o-donnellvb@cardiff.ac.uk.
Find articles by Rossjohn, J. in: JCI | PubMed | Google Scholar
1Systems Immunity Research Institute and Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, United Kingdom.
2Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, and
3ARC Centre of Excellence in Advanced Molecular Imaging, Monash University, Clayton, Victoria, Australia.
4Babraham Institute, Babraham Research Campus, Cambridge, United Kingdom.
Address correspondence to: Valerie B. O’Donnell, Systems Immunity Research Institute, Cardiff University, Heath Park, Cardiff, CF14 4XN, United Kingdom. Phone: 44.2920.687313; Email: o-donnellvb@cardiff.ac.uk.
Find articles by Wakelam, M. in: JCI | PubMed | Google Scholar
First published April 23, 2018 - More info
J Clin Invest. 2018;128(7):2670–2679. https://doi.org/10.1172/JCI97944.
Copyright © 2018, American Society for Clinical Investigation
Phospholipids comprise a large body of lipids that define cells and organelles by forming membrane structures. Importantly, their complex metabolism represents a highly controlled cellular signaling network that is essential for mounting an effective innate immune response. Phospholipids in innate cells are subject to dynamic regulation by enzymes, whose activities are highly responsive to activation status. Along with their metabolic products, they regulate multiple aspects of innate immune cell biology, including shape change, aggregation, blood clotting, and degranulation. Phospholipid hydrolysis provides substrates for cell-cell communication, enables regulation of hemostasis, immunity, thrombosis, and vascular inflammation, and is centrally important in cardiovascular disease and associated comorbidities. Phospholipids themselves are also recognized by innate-like T cells, which are considered essential for recognition of infection or cancer, as well as self-antigens. This Review describes the major phospholipid metabolic pathways present in innate immune cells and summarizes the formation and metabolism of phospholipids as well as their emerging roles in cell biology and disease.
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