Schematic depiction of Egr-1 induction in the vessel wall and mononuclear phagocytes/macrophages in response to hypoxemia. Oxygen deprivation causes expression of Egr-1 in mononuclear phagocytes and vascular smooth muscle cells thereby activating downstream target genes such as TF. Expression of TF in hypoxemic/ischemic vasculature provides a mechanism triggering the procoagulant pathway and, potentially, resulting in fibrin deposition.