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Usage Information

How does leptin restore euglycemia in insulin-deficient diabetes?
Douglas Oberlin, Christoph Buettner
Douglas Oberlin, Christoph Buettner
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How does leptin restore euglycemia in insulin-deficient diabetes?

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Abstract

Insulin replacement is the cornerstone of type 1 diabetes (T1D) treatment; however, glycemic control remains a challenge. Leptin has been shown to effectively restore euglycemia in rodent models of T1D; however, the mechanism or mechanisms by which leptin exerts glycemic control are unclear. In this issue of the JCI, Perry and colleagues provide evidence that suppression of lipolysis is a key facet of leptin-mediated restoration of euglycemia. However, more work remains to be done to fully understand the antidiabetic mechanisms of leptin.

Authors

Douglas Oberlin, Christoph Buettner

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Usage data is cumulative from February 2025 through February 2026.

Usage JCI PMC
Text version 475 26
PDF 130 12
Figure 113 6
Citation downloads 69 0
Totals 787 44
Total Views 831
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