Usage Information

Breaking down brain barrier breaches in cerebral malaria
Jens E.V. Petersen, … , Thomas Lavstsen, Alister Craig
Jens E.V. Petersen, … , Thomas Lavstsen, Alister Craig
Published September 19, 2016
Citation Information: J Clin Invest. 2016;126(10):3725-3727. https://doi.org/10.1172/JCI90188.
View: Text | PDF
Commentary

Breaking down brain barrier breaches in cerebral malaria

Abstract

Recent findings have linked brain swelling to death in cerebral malaria (CM). These observations have prompted a number of investigations into the mechanisms of this pathology with the goal of identifying potential therapeutic targets. In this issue of the JCI, Gallego-Delgado and colleagues present evidence that implicates angiotensin receptors and the relocation of β-catenin to the endothelial cell nucleus in CM. This study provides a renewed focus on infected erythrocyte debris as the cause of endothelial damage and challenges previous work implicating direct effects of infected erythrocyte sequestration in the brain as the major driver of disease. While this work provides potential therapeutic avenues for CM, it leaves a number of questions unanswered.

Authors

Jens E.V. Petersen, Thomas Lavstsen, Alister Craig

×

Usage data is cumulative from November 2019 through November 2020.

Usage JCI PMC
Text version 1,134 59
PDF 34 61
Citation downloads 8 0
Totals 1,176 120
Total Views 1,296

Usage information is collected from two different sources: this site (JCI) and Pubmed Central (PMC). JCI information (compiled daily) shows human readership based on methods we employ to screen out robotic usage. PMC information (aggregated monthly) is also similarly screened of robotic usage.

Various methods are used to distinguish robotic usage. For example, Google automatically scans articles to add to its search index and identifies itself as robotic; other services might not clearly identify themselves as robotic, or they are new or unknown as robotic. Because this activity can be misinterpreted as human readership, data may be re-processed periodically to reflect an improved understanding of robotic activity. Because of these factors, readers should consider usage information illustrative but subject to change.

Advertisement