TY - JOUR AU - Crewe, Clair AU - An, Yu Aaron AU - Scherer, Philipp E. T1 - The ominous triad of adipose tissue dysfunction: inflammation, fibrosis, and impaired angiogenesis PY - 2017/01/03/ AB - There are three dominant contributors to the pathogenesis of dysfunctional adipose tissue (AT) in obesity: unresolved inflammation, inappropriate extracellular matrix (ECM) remodeling and insufficient angiogenic potential. The interactions of these processes during AT expansion reflect both a linear progression as well as feed-forward mechanisms. For example, both inflammation and inadequate angiogenic remodeling can drive fibrosis, which can in turn promote migration of immune cells into adipose depots and impede further angiogenesis. Therefore, the relationship between the members of this triad is complex but important for our understanding of the pathogenesis of obesity. Here we untangle some of these intricacies to highlight the contributions of inflammation, angiogenesis, and the ECM to both “healthy” and “unhealthy” AT expansion. JF - The Journal of Clinical Investigation JA - J Clin Invest SN - 0021-9738 DO - 10.1172/JCI88883 VL - 127 IS - 1 UR - https://doi.org/10.1172/JCI88883 SP - 74 EP - 82 PB - The American Society for Clinical Investigation ER -