(A) 1 × 10⁶ CD45.2 WT or Kdm2b-null BM cells were injected into lethally irradiated CD45.1 recipients. Left: representative flow cytometric analysis showing the frequency (%) of CD45.2 and CD45.1 cells 1 and 2 months after transplantation. Right: cumulative bar graph from 5 independent transplantations. *P < 0.01 for CD45.1 cells. (B) Upper left: scatter plot of wbc in transplanted mice. Red dotted line indicates minimum physiological range. Upper right: stacked bar graph depicts the contribution (%) of lymphocytes, monocytes, and granulocytes. Bottom: bar graphs show the absolute number of lymphocytes, monocytes, granulocytes, platelets, and rbc. *P < 0.05; **P < 0.01; ***P < 0.001. (C) 1 × 10⁶ WT or Kdm2b^fl/fl CD45.2 BM cells were injected in a 1:1 ratio with CD45.1 competitor cells. Left: flow cytometric analysis shows the frequency (%) of CD45.2 and CD45.1 cells before and 10 weeks after pIpC administration. Right: line graph showing the ratio of CD45.2/CD45.1 cells in recipients over time. n = 4. *P < 0.05; **P < 0.01. (D) Stacked bar graphs showing the contribution (%) of CD45.2 and CD45.1 cells in B and T cells, granulocytes, and monocytes after pIpC administration. Bottom: ratio of CD45.2 to CD45.1 cells.