The DNA methyltransferases DNMT3A and DNMT3B are primarily responsible for de novo methylation of specific cytosine residues in CpG dinucleotides during mammalian development. While loss-of-function mutations in DNMT3A are highly recurrent in acute myeloid leukemia (AML),
Christopher B. Cole, Angela M. Verdoni, Shamika Ketkar, Elizabeth R. Leight, David A. Russler-Germain, Tamara L. Lamprecht, Ryan T. Demeter, Vincent Magrini, Timothy J. Ley
DNA methyltransferase activity of DNMT3A is required for aberrant self-renewal by PML-RARA ex vivo.