The presence of hypoxia within a tumor is associated with poor clinical outcome, which is often exacerbated by loss of the tumor suppressor p53. In the presence of functional p53, hypoxic conditions promote apoptosis; however, the p53-dependent genes that mediate this process are not well understood. In this issue of the
Zhong Yun, Peter M. Glazer
p53-dependent apoptosis via inhibition of AKT activation under severe hypoxia.