TY - JOUR AU - La Cava, Antonio T1 - Putting together the autoimmunity puzzle PY - 2015/06/01/ AB - Autoimmune diseases classically present with a complex etiology in which different factors concur in the generation and maintenance of autoreactive immune responses. Some mechanisms and pathways that lead to the development of imbalanced immune homeostasis and loss of self-tolerance have been identified as common to multiple autoimmune disorders. This Review series focuses on the general concepts of development and progression to pathogenic autoimmune phenotypes. A mechanistic discussion of the most recent advances in the field, together with related considerations of possible therapies, make this series of particular interest to both the basic and translational science communities. JF - The Journal of Clinical Investigation JA - J Clin Invest SN - 0021-9738 DO - 10.1172/JCI82041 VL - 125 IS - 6 UR - https://doi.org/10.1172/JCI82041 SP - 2184 EP - 2186 PB - The American Society for Clinical Investigation ER -