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Citations to this article

Follicular lymphoma: too many reminders for a memory B cell
Srividya Swaminathan, Markus Müschen
Srividya Swaminathan, Markus Müschen
Published November 10, 2014
Citation Information: J Clin Invest. 2014;124(12):5095-5098. https://doi.org/10.1172/JCI79189.
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Commentary

Follicular lymphoma: too many reminders for a memory B cell

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Abstract

Memory B cells are a dynamic subset of the mature B cell population that in some cases can reenter germinal centers (GCs) in response to iterative infections. Such a reactivation can lead to accumulation of genetic lesions in these cells, potentially from repetitive activation of the B cell mutator enzyme AID. Normal memory B cells do not survive repeated reentries into GCs. In this issue, Sungalee et al. demonstrate that memory B cells harboring the oncogenic BCL2:IGH translocation, which results in constitutive BCL2 expression, survive multiple GC entries upon repetitive immunization. Through these multiple GC reentries, the hallmark BCL2:IGH translocation enables AID-induced hypermutation and propagates clonal evolution toward malignant follicular lymphoma.

Authors

Srividya Swaminathan, Markus Müschen

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