Decreased insulin sensitivity, also referred to as insulin resistance (IR), is a
fundamental abnormality in patients with type 2 diabetes and a risk factor for
cardiovascular disease. While IR predisposition is heritable, the genetic basis remains
largely unknown. The GENEticS of Insulin Sensitivity consortium conducted a genome-wide
association study (GWAS) for direct measures of insulin sensitivity, such as euglycemic
clamp or insulin suppression test, in 2,764 European individuals, with replication in an
additional 2,860 individuals. The presence of a nonsynonymous variant of
N-acetyltransferase 2 (
Joshua W. Knowles, Weijia Xie, Zhongyang Zhang, Indumathi Chennemsetty, Themistocles L. Assimes, Jussi Paananen, Ola Hansson, James Pankow, Mark O. Goodarzi, Ivan Carcamo-Orive, Andrew P. Morris, Yii-Der I. Chen, Ville-Petteri Mäkinen, Andrea Ganna, Anubha Mahajan, Xiuqing Guo, Fahim Abbasi, Danielle M. Greenawalt, Pek Lum, Cliona Molony, Lars Lind, Cecilia Lindgren, Leslie J. Raffel, Philip S. Tsao, The RISC (Relationship between Insulin Sensitivity and Cardiovascular Disease) Consortium, The EUGENE2 (European Network on Functional Genomics of Type 2 Diabetes) Study, The GUARDIAN (Genetics UndeRlying DIAbetes in HispaNics) Consortium, The SAPPHIRe (Stanford Asian and Pacific Program for Hypertension and Insulin Resistance) Study, Eric E. Schadt, Jerome I. Rotter, Alan Sinaiko, Gerald Reaven, Xia Yang, Chao A. Hsiung, Leif Groop, Heather J. Cordell, Markku Laakso, Ke Hao, Erik Ingelsson, Timothy M. Frayling, Michael N. Weedon, Mark Walker, Thomas Quertermous
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