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Host-microbial interactions in the metabolism of therapeutic and diet-derived xenobiotics
Rachel N. Carmody, Peter J. Turnbaugh
Rachel N. Carmody, Peter J. Turnbaugh
Published August 8, 2014
Citation Information: J Clin Invest. 2014;124(10):4173-4181. https://doi.org/10.1172/JCI72335.
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Host-microbial interactions in the metabolism of therapeutic and diet-derived xenobiotics

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Abstract

Our associated microbial communities play a critical role in human health and predisposition to disease, but the degree to which they also shape therapeutic interventions is not well understood. Here, we integrate results from classic and current studies of the direct and indirect impacts of the gut microbiome on the metabolism of therapeutic drugs and diet-derived bioactive compounds. We pay particular attention to microbial influences on host responses to xenobiotics, adding to the growing consensus that treatment outcomes reflect our intimate partnership with the microbial world, and providing an initial framework from which to consider a more comprehensive view of pharmacology and nutrition.

Authors

Rachel N. Carmody, Peter J. Turnbaugh

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Figure 3

Mechanisms of microbial modulation of host xenobiotic metabolism for select therapeutic and diet-derived compounds.

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Mechanisms of microbial modulation of host xenobiotic metabolism for sel...
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