TY - JOUR AU - Hensley, Christopher T. AU - Wasti, Ajla T. AU - DeBerardinis, Ralph J. T1 - Glutamine and cancer: cell biology, physiology, and clinical opportunities PY - 2013/09/03/ AB - Glutamine is an abundant and versatile nutrient that participates in energy formation, redox homeostasis, macromolecular synthesis, and signaling in cancer cells. These characteristics make glutamine metabolism an appealing target for new clinical strategies to detect, monitor, and treat cancer. Here we review the metabolic functions of glutamine as a super nutrient and the surprising roles of glutamine in supporting the biological hallmarks of malignancy. We also review recent efforts in imaging and therapeutics to exploit tumor cell glutamine dependence, discuss some of the challenges in this arena, and suggest a disease-focused paradigm to deploy these emerging approaches. JF - The Journal of Clinical Investigation JA - J Clin Invest SN - 0021-9738 DO - 10.1172/JCI69600 VL - 123 IS - 9 UR - https://doi.org/10.1172/JCI69600 SP - 3678 EP - 3684 PB - The American Society for Clinical Investigation ER -