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MicroRNAs in cardiovascular disease: from pathogenesis to prevention and treatment
Daniel Quiat, Eric N. Olson
Daniel Quiat, Eric N. Olson
Published January 2, 2013
Citation Information: J Clin Invest. 2013;123(1):11-18. https://doi.org/10.1172/JCI62876.
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Review Series

MicroRNAs in cardiovascular disease: from pathogenesis to prevention and treatment

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Abstract

The management of cardiovascular risk through lifestyle modification and pharmacotherapy is paramount to the prevention of cardiovascular disease. Epidemiological studies have identified obesity, dyslipidemia, diabetes, and hypertension as interrelated factors that negatively affect cardiovascular health. Recently, genetic and pharmacological evidence in model systems has implicated microRNAs as dynamic modifiers of disease pathogenesis. An expanded understanding of the function of microRNAs in gene regulatory networks associated with cardiovascular risk will enable identification of novel genetic mechanisms of disease and inform the development of innovative therapeutic strategies.

Authors

Daniel Quiat, Eric N. Olson

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Figure 2

Role of miR-33 and miR-122 in hepatic lipid metabolism.

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Role of miR-33 and miR-122 in hepatic lipid metabolism.
The SREBF locus ...
The SREBF locus encodes the lipogenic transcription factor SREBP and miR-33, which represses mRNA transcripts of genes in the fatty acid (FA) β-oxidation and cholesterol efflux pathways. miR-122 promotes lipid synthesis by supporting the expression of lipid biosynthetic genes, and dampens fatty acid oxidation by inhibiting phosphorylation of AMPKa by an unknown mechanism.

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ISSN: 0021-9738 (print), 1558-8238 (online)

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