Advertisement
APOBEC3G promotes liver metastasis in an orthotopic mouse model of colorectal cancer and predicts human hepatic metastasis
Qingqing Ding, Chun-Ju Chang, Xiaoming Xie, Weiya Xia, Jer-Yen Yang, Shao-Chun Wang, Yan Wang, Jiahong Xia, Libo Chen, Changchun Cai, Huabin Li, Chia-Jui Yen, Hsu-Ping Kuo, Dung-Fang Lee, Jingyu Lang, Longfei Huo, Xiaoyun Cheng, Yun-Ju Chen, Chia-Wei Li, Long-Bin Jeng, Jennifer L. Hsu, Long-Yuan Li, Alai Tan, Steven A. Curley, Lee M. Ellis, Raymond N. DuBois, and Mien-Chie Hung
Find articles by Ding, Q. in: JCI | PubMed | Google Scholar
Find articles by Chang, C. in: JCI | PubMed | Google Scholar
Find articles by Xie, X. in: JCI | PubMed | Google Scholar
Find articles by Xia, W. in: JCI | PubMed | Google Scholar
Find articles by Yang, J. in: JCI | PubMed | Google Scholar
Find articles by Wang, S. in: JCI | PubMed | Google Scholar
Find articles by Wang, Y. in: JCI | PubMed | Google Scholar
Find articles by Xia, J. in: JCI | PubMed | Google Scholar
Find articles by Chen, L. in: JCI | PubMed | Google Scholar
Find articles by Cai, C. in: JCI | PubMed | Google Scholar
Find articles by Li, H. in: JCI | PubMed | Google Scholar
Find articles by Yen, C. in: JCI | PubMed | Google Scholar
Find articles by Kuo, H. in: JCI | PubMed | Google Scholar
Find articles by Lee, D. in: JCI | PubMed | Google Scholar
Find articles by Lang, J. in: JCI | PubMed | Google Scholar
Find articles by Huo, L. in: JCI | PubMed | Google Scholar
Find articles by Cheng, X. in: JCI | PubMed | Google Scholar
Find articles by Chen, Y. in: JCI | PubMed | Google Scholar
Find articles by Li, C. in: JCI | PubMed | Google Scholar
Find articles by Jeng, L. in: JCI | PubMed | Google Scholar
Find articles by Hsu, J. in: JCI | PubMed | Google Scholar
Find articles by Li, L. in: JCI | PubMed | Google Scholar
Find articles by Tan, A. in: JCI | PubMed | Google Scholar
Find articles by Curley, S. in: JCI | PubMed | Google Scholar
Find articles by Ellis, L. in: JCI | PubMed | Google Scholar
Find articles by DuBois, R. in: JCI | PubMed | Google Scholar
Find articles by Hung, M. in: JCI | PubMed | Google Scholar
Published January 3, 2012 - More info
J Clin Invest. 2012;122(1):419–419. https://doi.org/10.1172/JCI61734.
© 2012 The American Society for Clinical Investigation
Related article:
Abstract
Colorectal cancer is the second leading cause of death from cancer in the United States. Metastases in the liver, the most common metastatic site for colorectal cancer, are found in one-third of the patients who die of colorectal cancer. Currently, the genes and molecular mechanisms that are functionally critical in modulating colorectal cancer hepatic metastasis remain unclear. Here, we report our studies using functional selection in an orthotopic mouse model of colorectal cancer to identify a set of genes that play an important role in mediating colorectal cancer liver metastasis. These genes included APOBEC3G, CD133, LIPC, and S100P. Clinically, we found these genes to be highly expressed in a cohort of human hepatic metastasis and their primary colorectal tumors, suggesting that it might be possible to use these genes to predict the likelihood of hepatic metastasis. We have further revealed what we believe to be a novel mechanism in which APOBEC3G promotes colorectal cancer hepatic metastasis through inhibition of miR-29–mediated suppression of MMP2. Together, our data elucidate key factors and mechanisms involved in colorectal cancer liver metastasis, which could be potential targets for diagnosis and treatment.
Authors
Qingqing Ding, Chun-Ju Chang, Xiaoming Xie, Weiya Xia, Jer-Yen Yang, Shao-Chun Wang, Yan Wang, Jiahong Xia, Libo Chen, Changchun Cai, Huabin Li, Chia-Jui Yen, Hsu-Ping Kuo, Dung-Fang Lee, Jingyu Lang, Longfei Huo, Xiaoyun Cheng, Yun-Ju Chen, Chia-Wei Li, Long-Bin Jeng, Jennifer L. Hsu, Long-Yuan Li, Alai Tan, Steven A. Curley, Lee M. Ellis, Raymond N. DuBois, Mien-Chie Hung
Original citation: J. Clin. Invest. 2011;121(11):4526–4536. doi:10.1172/JCI45008.
Citation for this corrigendum: J. Clin. Invest. 2012;122(1):419. doi:10.1172/JCI61734.
In the author list, Changchun Cai’s name was inadvertently misspelled. The correct author list appears above.
The authors regret the error.
Copyright © 2021 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)