Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Alerts
  • Advertising/recruitment
  • Subscribe
  • Contact
  • Current Issue
  • Past Issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Author's Takes
  • Reviews
    • View all reviews ...
    • 100th Anniversary of Insulin's Discovery (Jan 2021)
    • Hypoxia-inducible factors in disease pathophysiology and therapeutics (Oct 2020)
    • Latency in Infectious Disease (Jul 2020)
    • Immunotherapy in Hematological Cancers (Apr 2020)
    • Big Data's Future in Medicine (Feb 2020)
    • Mechanisms Underlying the Metabolic Syndrome (Oct 2019)
    • Reparative Immunology (Jul 2019)
    • View all review series ...
  • Viewpoint
  • Collections
    • Recently published
    • In-Press Preview
    • Commentaries
    • Concise Communication
    • Editorials
    • Viewpoint
    • Top read articles
  • Clinical Medicine
  • JCI This Month
    • Current issue
    • Past issues

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Author's Takes
  • Recently published
  • In-Press Preview
  • Commentaries
  • Concise Communication
  • Editorials
  • Viewpoint
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Alerts
  • Advertising/recruitment
  • Subscribe
  • Contact
Top
  • View PDF
  • Download citation information
  • Send a letter
  • Share this article
  • Terms of use
  • Standard abbreviations
  • Need Help? E-mail the JCI
  • Top
  • Version history
  • Article usage
  • Citations to this article

Advertisement

Corrigendum Free access | 10.1172/JCI61734

APOBEC3G promotes liver metastasis in an orthotopic mouse model of colorectal cancer and predicts human hepatic metastasis

Qingqing Ding, Chun-Ju Chang, Xiaoming Xie, Weiya Xia, Jer-Yen Yang, Shao-Chun Wang, Yan Wang, Jiahong Xia, Libo Chen, Changchun Cai, Huabin Li, Chia-Jui Yen, Hsu-Ping Kuo, Dung-Fang Lee, Jingyu Lang, Longfei Huo, Xiaoyun Cheng, Yun-Ju Chen, Chia-Wei Li, Long-Bin Jeng, Jennifer L. Hsu, Long-Yuan Li, Alai Tan, Steven A. Curley, Lee M. Ellis, Raymond N. DuBois, and Mien-Chie Hung

Find articles by Ding, Q. in: JCI | PubMed | Google Scholar

Find articles by Chang, C. in: JCI | PubMed | Google Scholar

Find articles by Xie, X. in: JCI | PubMed | Google Scholar

Find articles by Xia, W. in: JCI | PubMed | Google Scholar

Find articles by Yang, J. in: JCI | PubMed | Google Scholar

Find articles by Wang, S. in: JCI | PubMed | Google Scholar

Find articles by Wang, Y. in: JCI | PubMed | Google Scholar

Find articles by Xia, J. in: JCI | PubMed | Google Scholar

Find articles by Chen, L. in: JCI | PubMed | Google Scholar

Find articles by Cai, C. in: JCI | PubMed | Google Scholar

Find articles by Li, H. in: JCI | PubMed | Google Scholar

Find articles by Yen, C. in: JCI | PubMed | Google Scholar

Find articles by Kuo, H. in: JCI | PubMed | Google Scholar

Find articles by Lee, D. in: JCI | PubMed | Google Scholar

Find articles by Lang, J. in: JCI | PubMed | Google Scholar

Find articles by Huo, L. in: JCI | PubMed | Google Scholar

Find articles by Cheng, X. in: JCI | PubMed | Google Scholar

Find articles by Chen, Y. in: JCI | PubMed | Google Scholar

Find articles by Li, C. in: JCI | PubMed | Google Scholar

Find articles by Jeng, L. in: JCI | PubMed | Google Scholar

Find articles by Hsu, J. in: JCI | PubMed | Google Scholar

Find articles by Li, L. in: JCI | PubMed | Google Scholar

Find articles by Tan, A. in: JCI | PubMed | Google Scholar

Find articles by Curley, S. in: JCI | PubMed | Google Scholar

Find articles by Ellis, L. in: JCI | PubMed | Google Scholar

Find articles by DuBois, R. in: JCI | PubMed | Google Scholar

Find articles by Hung, M. in: JCI | PubMed | Google Scholar

Published January 3, 2012 - More info

Published in Volume 122, Issue 1 on January 3, 2012
J Clin Invest. 2012;122(1):419–419. https://doi.org/10.1172/JCI61734.
© 2012 The American Society for Clinical Investigation
Published January 3, 2012 - Version history
View PDF

Related article:

APOBEC3G promotes liver metastasis in an orthotopic mouse model of colorectal cancer and predicts human hepatic metastasis
Qingqing Ding, … , Raymond N. DuBois, Mien-Chie Hung
Qingqing Ding, … , Raymond N. DuBois, Mien-Chie Hung
Research Article Oncology

APOBEC3G promotes liver metastasis in an orthotopic mouse model of colorectal cancer and predicts human hepatic metastasis

  • Text
  • PDF
Abstract

Colorectal cancer is the second leading cause of death from cancer in the United States. Metastases in the liver, the most common metastatic site for colorectal cancer, are found in one-third of the patients who die of colorectal cancer. Currently, the genes and molecular mechanisms that are functionally critical in modulating colorectal cancer hepatic metastasis remain unclear. Here, we report our studies using functional selection in an orthotopic mouse model of colorectal cancer to identify a set of genes that play an important role in mediating colorectal cancer liver metastasis. These genes included APOBEC3G, CD133, LIPC, and S100P. Clinically, we found these genes to be highly expressed in a cohort of human hepatic metastasis and their primary colorectal tumors, suggesting that it might be possible to use these genes to predict the likelihood of hepatic metastasis. We have further revealed what we believe to be a novel mechanism in which APOBEC3G promotes colorectal cancer hepatic metastasis through inhibition of miR-29–mediated suppression of MMP2. Together, our data elucidate key factors and mechanisms involved in colorectal cancer liver metastasis, which could be potential targets for diagnosis and treatment.

Authors

Qingqing Ding, Chun-Ju Chang, Xiaoming Xie, Weiya Xia, Jer-Yen Yang, Shao-Chun Wang, Yan Wang, Jiahong Xia, Libo Chen, Changchun Cai, Huabin Li, Chia-Jui Yen, Hsu-Ping Kuo, Dung-Fang Lee, Jingyu Lang, Longfei Huo, Xiaoyun Cheng, Yun-Ju Chen, Chia-Wei Li, Long-Bin Jeng, Jennifer L. Hsu, Long-Yuan Li, Alai Tan, Steven A. Curley, Lee M. Ellis, Raymond N. DuBois, Mien-Chie Hung

×

Original citation: J. Clin. Invest. 2011;121(11):4526–4536. doi:10.1172/JCI45008.

Citation for this corrigendum: J. Clin. Invest. 2012;122(1):419. doi:10.1172/JCI61734.

In the author list, Changchun Cai’s name was inadvertently misspelled. The correct author list appears above.

The authors regret the error.

Version history
  • Version 1 (January 3, 2012): No description

Article tools

  • View PDF
  • Download citation information
  • Send a letter
  • Share this article
  • Terms of use
  • Standard abbreviations
  • Need Help? E-mail the JCI

Metrics

  • Article usage
  • Citations to this article

Go to

  • Top
  • Version history
Advertisement
Advertisement
Follow JCI:
Copyright © 2021 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts