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Usage Information

Ceramides as modulators of cellular and whole-body metabolism
Benjamin T. Bikman, Scott A. Summers
Benjamin T. Bikman, Scott A. Summers
Published November 1, 2011
Citation Information: J Clin Invest. 2011;121(11):4222-4230. https://doi.org/10.1172/JCI57144.
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Science in Medicine

Ceramides as modulators of cellular and whole-body metabolism

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Abstract

Nearly all stress stimuli (e.g., inflammatory cytokines, glucocorticoids, chemotherapeutics, etc.) induce sphingolipid synthesis, leading to the accumulation of ceramides and ceramide metabolites. While the role of these lipids in the regulation of cell growth and death has been studied extensively, recent studies suggest that a primary consequence of ceramide accumulation is an alteration in metabolism. In both cell-autonomous systems and complex organisms, ceramides modify intracellular signaling pathways to slow anabolism, ensuring that catabolism ensues. These ceramide actions have important implications for diseases associated with obesity, such as diabetes and cardiovascular disease.

Authors

Benjamin T. Bikman, Scott A. Summers

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Usage data is cumulative from May 2021 through May 2022.

Usage JCI PMC
Text version 1,957 761
PDF 284 112
Figure 440 9
Citation downloads 25 0
Totals 2,706 882
Total Views 3,588
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Usage information is collected from two different sources: this site (JCI) and Pubmed Central (PMC). JCI information (compiled daily) shows human readership based on methods we employ to screen out robotic usage. PMC information (aggregated monthly) is also similarly screened of robotic usage.

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