Abstract
Insulin secretion is a highly dynamic process regulated by various factors including nutrients, hormones, and neuronal inputs. The dynamics of insulin secretion can be studied at different levels: the single β cell, pancreatic islet, whole pancreas, and the intact organism. Studies have begun to analyze cellular and molecular mechanisms underlying dynamics of insulin secretion. This review focuses on our current understanding of the dynamics of insulin secretion in vitro and in vivo and discusses their clinical relevance.
Authors
Susumu Seino, Tadao Shibasaki, Kohtaro Minami
Figure 4
Changes in AIRg relative to changes in SI index in Pima Indian subjects in whom glucose tolerance deteriorated from normal glucose tolerance (NGT) to impaired glucose tolerance (IGT) to diabetes (DIA) (progressors) and in subjects who retained NGT (nonprogressors).
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ISSN: 0021-9738 (print), 1558-8238 (online)