TY - JOUR AU - Patrick, David M. AU - Montgomery, Rusty L. AU - Qi, Xiaoxia AU - Obad, Susanna AU - Kauppinen, Sakari AU - Hill, Joseph A. AU - van Rooij, Eva AU - Olson, Eric N. T1 - Stress-dependent cardiac remodeling occurs in the absence of microRNA-21 in mice PY - 2010/11/01/ AB - MicroRNAs inhibit mRNA translation or promote mRNA degradation by binding complementary sequences in 3′ untranslated regions of target mRNAs. MicroRNA-21 (miR-21) is upregulated in response to cardiac stress, and its inhibition by a cholesterol-modified antagomir has been reported to prevent cardiac hypertrophy and fibrosis in rodents in response to pressure overload. In contrast, we have shown here that miR-21–null mice are normal and, in response to a variety of cardiac stresses, display cardiac hypertrophy, fibrosis, upregulation of stress-responsive cardiac genes, and loss of cardiac contractility comparable to wild-type littermates. Similarly, inhibition of miR-21 through intravenous delivery of a locked nucleic acid–modified (LNA-modified) antimiR oligonucleotide also failed to block the remodeling response of the heart to stress. We therefore conclude that miR-21 is not essential for pathological cardiac remodeling. JF - The Journal of Clinical Investigation JA - J Clin Invest SN - 0021-9738 DO - 10.1172/JCI43604 VL - 120 IS - 11 UR - https://doi.org/10.1172/JCI43604 SP - 3912 EP - 3916 PB - The American Society for Clinical Investigation ER -