TY - JOUR AU - Aslan, Hadi AU - Kimelman-Bleich, Nadav AU - Pelled, Gadi AU - Gazit, Dan T1 - Molecular targets for tendon neoformation PY - 2008/02/01/ AB - Tendons and ligaments are unique forms of connective tissue that are considered an integral part of the musculoskeletal system. The ultimate function of tendon is to connect muscles to bones and to conduct the forces generated by muscle contraction into movements of the joints, whereas ligaments connect bone to bone and provide joint stabilization. Unfortunately, the almost acellular and collagen I–rich structure of tendons and ligaments makes them very poorly regenerating tissues. Injured tendons and ligaments are considered a major clinical challenge in orthopedic and sports medicine. This Review discusses the several factors that might serve as molecular targets that upon activation can enhance or lead to tendon neoformation. JF - The Journal of Clinical Investigation JA - J Clin Invest SN - 0021-9738 DO - 10.1172/JCI33944 VL - 118 IS - 2 UR - https://doi.org/10.1172/JCI33944 SP - 439 EP - 444 PB - The American Society for Clinical Investigation ER -