TY - JOUR AU - Lees, Jason R. AU - Cross, Anne H. T1 - A little stress is good: IFN-γ, demyelination, and multiple sclerosis PY - 2007/02/01/ AB - The exact role(s) of the cytokine IFN-γ in the demyelinating disease multiple sclerosis remain controversial, with evidence suggesting both detrimental and protective effects of the cytokine in MS and MS models such as EAE. The study by Lin and coworkers in this issue of the JCI produces evidence that protective effects of IFN-γ on mature oligodendrocytes during EAE induction are mediated via activation of the pancreatic ER kinase (PERK), resulting in induction of the endoplasmic reticular stress response pathway (see the related article beginning on page 448). Modulation of this stress pathway has what we believe to be novel therapeutic potential for MS. JF - The Journal of Clinical Investigation JA - J Clin Invest SN - 0021-9738 DO - 10.1172/JCI31254 VL - 117 IS - 2 UR - https://doi.org/10.1172/JCI31254 SP - 297 EP - 299 PB - The American Society for Clinical Investigation ER -