Molecular regulation of HDL metabolism and function: implications for novel therapies
Daniel J. Rader
Daniel J. Rader
Published December 1, 2006
Citation Information: J Clin Invest. 2006;116(12):3090-3100. https://doi.org/10.1172/JCI30163.
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Science in Medicine

Molecular regulation of HDL metabolism and function: implications for novel therapies

Abstract

HDL metabolism represents a major target for the development of therapies intended to reduce the risk of atherosclerotic cardiovascular disease. HDL metabolism is complex and involves dissociation of HDL apolipoprotein and HDL cholesterol metabolism. Advances in our understanding of the molecular regulation of HDL metabolism, macrophage cholesterol efflux, and HDL function will lead to a variety of novel therapeutics.

Authors

Daniel J. Rader

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Figure 2

Pathways of HDL cholesterol uptake by the liver.

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Pathways of HDL cholesterol uptake by the liver. HDL-CE and HDL free cho...
HDL-CE and HDL free cholesterol can be directly and selectively taken up by the liver via SR-BI. Alternatively, HDL-CE can be transferred to apoB-containing lipoproteins by CETP and then taken up by liver via the LDLR. In the hepatocyte, CE is hydrolyzed to free cholesterol, which is either excreted directly into the bile or converted to bile acid (BA) and excreted into the bile.