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Megakaryocyte biology and related disorders
Liyan Pang, … , Mitchell J. Weiss, Mortimer Poncz
Liyan Pang, … , Mitchell J. Weiss, Mortimer Poncz
Published December 1, 2005
Citation Information: J Clin Invest. 2005;115(12):3332-3338. https://doi.org/10.1172/JCI26720.
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Review Series

Megakaryocyte biology and related disorders

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Abstract

Platelets, derived from megakaryocytes, have an essential role in thrombosis and hemostasis. Over the past 10 years, a great deal of new information has been obtained concerning the various aspects of hematopoiesis necessary to maintain a steady-state platelet level to support physiologic hemostasis. Here we discuss the differentiation of HSCs into megakaryocytes, with emphasis on the key cytokine signaling pathways and hematopoietic transcription factors. Recent insight into these processes elucidates the molecular bases of numerous acquired and inherited hematologic disorders. It is anticipated that the growing knowledge in these areas may be exploited for new therapeutic strategies to modulate both platelet numbers and their thrombogenicity.

Authors

Liyan Pang, Mitchell J. Weiss, Mortimer Poncz

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Figure 3

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Assembly of transcription factor complex at a megakaryocyte-specific gen...
Assembly of transcription factor complex at a megakaryocyte-specific gene. A schematic representation of the proximal promoter region of a hypothetical megakaryocyte-specific gene modeled after the Itga2b gene. GATA-1 is shown in the middle binding to its known consensus sequence (69) and interacting with FOG-1, Fli-1, and CBFA2 of the RUNX complex (each interaction is indicated by a 2-headed arrow). Fli-1 and CBFA2 bind to their adjacent cognate on the DNA (89, 122), while FOG-1 is recruited through its interactions with the N-terminal zinc finger of GATA-1. In turn, FOG-1 recruits the NuRD complex and other nuclear factors.

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ISSN: 0021-9738 (print), 1558-8238 (online)

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