TY - JOUR AU - Roden, Dan M. AU - Viswanathan, Prakash C. T1 - Genetics of acquired long QT syndrome PY - 2005/08/01/ AB - The QT interval is the electrocardiographic manifestation of ventricular repolarization, is variable under physiologic conditions, and is measurably prolonged by many drugs. Rarely, however, individuals with normal base-line intervals may display exaggerated QT interval prolongation, and the potentially fatal polymorphic ventricular tachycardia torsade de pointes, with drugs or other environmental stressors such as heart block or heart failure. This review summarizes the molecular and cellular mechanisms underlying this acquired or drug-induced form of long QT syndrome, describes approaches to the analysis of a role for DNA variants in the mediation of individual susceptibility, and proposes that these concepts may be generalizable to common acquired arrhythmias. JF - The Journal of Clinical Investigation JA - J Clin Invest SN - 0021-9738 DO - 10.1172/JCI25539 VL - 115 IS - 8 UR - https://doi.org/10.1172/JCI25539 SP - 2025 EP - 2032 PB - The American Society for Clinical Investigation ER -