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Usage Information

Soy diet worsens heart disease in mice
Brian L. Stauffer, … , Elizabeth D. Luczak, Leslie A. Leinwand
Brian L. Stauffer, … , Elizabeth D. Luczak, Leslie A. Leinwand
Published January 4, 2006
Citation Information: J Clin Invest. 2006;116(1):209-216. https://doi.org/10.1172/JCI24676.
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Research Article Cardiology

Soy diet worsens heart disease in mice

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Abstract

We report that dietary modification from a soy-based diet to a casein-based diet radically improves disease indicators and cardiac function in a transgenic mouse model of hypertrophic cardiomyopathy. On a soy diet, males with a mutation in the α-myosin heavy chain gene progress to dilation and heart failure. However, males fed a casein diet no longer deteriorate to severe, dilated cardiomyopathy. Remarkably, their LV size and contractile function are preserved. Further, this diet prevents a number of pathologic indicators in males, including fibrosis, induction of β-myosin heavy chain, inactivation of glycogen synthase kinase 3β (GSK3β), and caspase-3 activation.

Authors

Brian L. Stauffer, John P. Konhilas, Elizabeth D. Luczak, Leslie A. Leinwand

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Usage data is cumulative from June 2024 through June 2025.

Usage JCI PMC
Text version 909 49
PDF 66 25
Figure 273 6
Citation downloads 71 0
Totals 1,319 80
Total Views 1,399
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