TY - JOUR AU - Fauci, Anthony S. AU - Challberg, Mark D. T1 - Host-based antipoxvirus therapeutic strategies: turning the tables PY - 2005/02/01/ AB - The potential threat of the smallpox virus as a bioterror weapon has long been recognized, and the need for developing suitable countermeasures has become especially acute following the events of September 2001. Traditional antiviral agents interfere with viral proteins or functions. In a new study, Yang et al. focus instead on host cellular pathways used by the virus. A drug that interferes with the cellular ErbB-1 signal transduction pathway, activated by smallpox growth factor, sheds new light on how the virus replicates in the cell. Drugs that target the ErbB-signaling pathways represent a promising new class of antiviral agents. JF - The Journal of Clinical Investigation JA - J Clin Invest SN - 0021-9738 DO - 10.1172/JCI24270 VL - 115 IS - 2 UR - https://doi.org/10.1172/JCI24270 SP - 231 EP - 233 PB - The American Society for Clinical Investigation ER -