TY - JOUR AU - Friedman, Scott L. T1 - Mac the knife? Macrophages– the double-edged sword of hepatic fibrosis PY - 2005/01/03/ AB - Progression of hepatic fibrosis requires sustained inflammation leading to activation of stellate cells into a fibrogenic and proliferative cell type, whereas regression is associated with stellate cell apoptosis. The contribution of hepatic macrophages to these events has been largely overlooked. However, a study in this issue of the JCI demonstrates that macrophages play pivotal but divergent roles, favoring ECM accumulation during ongoing injury but enhancing matrix degradation during recovery. These findings underscore the potential importance of hepatic macrophages in regulating both stellate cell biology and ECM degradation during regression of hepatic fibrosis. JF - The Journal of Clinical Investigation JA - J Clin Invest SN - 0021-9738 DO - 10.1172/JCI23928 VL - 115 IS - 1 UR - https://doi.org/10.1172/JCI23928 SP - 29 EP - 32 PB - The American Society for Clinical Investigation ER -