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Usage Information

Acid sensing in renal epithelial cells
Stephen L. Gluck
Stephen L. Gluck
Published December 15, 2004
Citation Information: J Clin Invest. 2004;114(12):1696-1699. https://doi.org/10.1172/JCI23864.
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Commentary

Acid sensing in renal epithelial cells

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Abstract

The kidney adjusts net acid excretion to match production with exquisite precision, despite little or no change in the plasma bicarbonate concentration. The acid-sensing pathway that signals the kidney to increase acid secretion involves activation of the proto-oncogene c-Src. A new study in this issue shows that proline-rich tyrosine kinase 2 (Pyk2) is responsible for acid-induced activation of c-Src and is essential for acid sensing in renal epithelial cells. The findings implicate a broader role for Pyk2 in acid-base homeostasis in bone and other tissues beyond the kidney.

Authors

Stephen L. Gluck

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