TY - JOUR AU - Gluck, Stephen L. T1 - Acid sensing in renal epithelial cells PY - 2004/12/15/ AB - The kidney adjusts net acid excretion to match production with exquisite precision, despite little or no change in the plasma bicarbonate concentration. The acid-sensing pathway that signals the kidney to increase acid secretion involves activation of the proto-oncogene c-Src. A new study in this issue shows that proline-rich tyrosine kinase 2 (Pyk2) is responsible for acid-induced activation of c-Src and is essential for acid sensing in renal epithelial cells. The findings implicate a broader role for Pyk2 in acid-base homeostasis in bone and other tissues beyond the kidney. JF - The Journal of Clinical Investigation JA - J Clin Invest SN - 0021-9738 DO - 10.1172/JCI23864 VL - 114 IS - 12 UR - https://doi.org/10.1172/JCI23864 SP - 1696 EP - 1699 PB - The American Society for Clinical Investigation ER -