Richard Havel, Howard Eder, and the evolution of lipoprotein analysis
Scott M. Grundy
Scott M. Grundy
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Retrospectives

Richard Havel, Howard Eder, and the evolution of lipoprotein analysis

Abstract

In 1956, the JCI published a paper by Richard Havel, Howard Eder, and Joseph Bragdon on a method using an ultracentrifuge to physically separate plasma lipoproteins and chemical methods to analyze their lipid constituents. This paper has been much cited (7081 times as of this writing) in part because it represents a solid method that, with various modifications, has been applicable for the study of lipoproteins for almost half a century.

Authors

Scott M. Grundy

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Figure 2

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Spinco Model L preparative ultracentrifuge used in the paper by Havel et...
Spinco Model L preparative ultracentrifuge used in the paper by Havel et al. (1). This ultracentrifuge was employed almost exclusively for lipoprotein isolation by early lipoprotein researchers. There were more than 3000 Model Ls sold. Isolation of lipoproteins typically was carried out by centrifugation at 105,000 g for 20 to 22 hours (1). Image courtesy of Beckman Coulter Inc.