TY - JOUR AU - Sarantopoulos, Stefanie AU - Lu, Linrong AU - Cantor, Harvey T1 - Qa-1 restriction of CD8+ suppressor T cells PY - 2004/11/01/ AB - There is increasing evidence that the immune response can be inhibited by several T cell subsets, including NK T cells, CD25+CD4+ T cells, and a subpopulation of CD8+ T cells. Animal model studies of multiple sclerosis have suggested an important role for suppressor CD8+ T cells in protection against disease recurrence and exacerbation. The molecular lynchpin of CD8+ suppressive activity is the murine MHC molecule Qa-1, termed HLA-E in humans. Here we summarize findings from work on Qa-1 that have begun to delineate suppressor CD8+ T cells and their mechanisms of action in the context of self tolerance and autoimmune disease. JF - The Journal of Clinical Investigation JA - J Clin Invest SN - 0021-9738 DO - 10.1172/JCI23152 VL - 114 IS - 9 UR - https://doi.org/10.1172/JCI23152 SP - 1218 EP - 1221 PB - The American Society for Clinical Investigation ER -