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Usage Information

Unlocking the secrets of the pancreatic β cell: man and mouse provide the key
Andrew T. Hattersley
Andrew T. Hattersley
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Commentary

Unlocking the secrets of the pancreatic β cell: man and mouse provide the key

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Abstract

Failure of the pancreas to secrete sufficient insulin results in type 2 diabetes, but the pathogenesis of pancreatic β cell dysfunction is still poorly understood. New insights into β cell failure come from defining the genes involved in rare genetic subtypes of diabetes and creating appropriate animal models. A new mouse model of transient neonatal diabetes mellitus emphasizes that both the number of β cells and their function are critical for insulin secretion and may be regulated by imprinted genes.

Authors

Andrew T. Hattersley

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Usage data is cumulative from January 2025 through January 2026.

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Copyright © 2026 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

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