TY - JOUR AU - O’Shaughnessy, Kevin M. AU - Karet, Fiona E. T1 - Salt handling and hypertension PY - 2004/04/15/ AB - The kidney plays a central role in our ability to maintain appropriate sodium balance, which is critical to determination of blood pressure. In this review we outline current knowledge of renal salt handling at the molecular level, and, given that Westernized societies consume more salt than is required for normal physiology, we examine evidence that the lowering of salt intake can combat hypertension. JF - The Journal of Clinical Investigation JA - J Clin Invest SN - 0021-9738 DO - 10.1172/JCI21560 VL - 113 IS - 8 UR - https://doi.org/10.1172/JCI21560 SP - 1075 EP - 1081 PB - The American Society for Clinical Investigation ER -