Combined talimogene laherparepvec and binimetinib in <i>NRAS</i>-mutated melanoma induces anti-tumor immunity

Tony Yao; Rita E. Chen; Melissa Yamada; J. Russell Moore; Marissa Jimenez; Tammy Huang; Lynn Cornelius; George Ansstas; Naresha Saligrama; David Y. Chen

doi:10.1172/JCI211137

¹Department of Medicine, Washington University, St. Louis, United States of America

²Department of Neurology, Washington University, St. Louis, United States of America

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¹Department of Medicine, Washington University, St. Louis, United States of America

²Department of Neurology, Washington University, St. Louis, United States of America

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¹Department of Medicine, Washington University, St. Louis, United States of America

²Department of Neurology, Washington University, St. Louis, United States of America

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¹Department of Medicine, Washington University, St. Louis, United States of America

²Department of Neurology, Washington University, St. Louis, United States of America

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¹Department of Medicine, Washington University, St. Louis, United States of America

²Department of Neurology, Washington University, St. Louis, United States of America

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¹Department of Medicine, Washington University, St. Louis, United States of America

²Department of Neurology, Washington University, St. Louis, United States of America

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¹Department of Medicine, Washington University, St. Louis, United States of America

²Department of Neurology, Washington University, St. Louis, United States of America

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¹Department of Medicine, Washington University, St. Louis, United States of America

²Department of Neurology, Washington University, St. Louis, United States of America

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¹Department of Medicine, Washington University, St. Louis, United States of America

²Department of Neurology, Washington University, St. Louis, United States of America

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¹Department of Medicine, Washington University, St. Louis, United States of America

²Department of Neurology, Washington University, St. Louis, United States of America

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J Clin Invest. https://doi.org/10.1172/JCI211137.
Copyright © 2026, Yao et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

Published September 29, 2026 - Version history

Combined talimogene laherparepvec and binimetinib in NRAS-mutated melanoma induces anti-tumor immunity

Tony Yao,¹ Rita E. Chen,¹ Melissa Yamada,¹ J. Russell Moore,¹ Marissa Jimenez,¹ Tammy Huang,² Lynn Cornelius,¹ George Ansstas,¹ Naresha Saligrama,² and David Y. Chen¹

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Combined talimogene laherparepvec and binimetinib in NRAS-mutated melanoma induces anti-tumor immunity

Tony Yao,1 Rita E. Chen,1 Melissa Yamada,1 J. Russell Moore,1 Marissa Jimenez,1 Tammy Huang,2 Lynn Cornelius,1 George Ansstas,1 Naresha Saligrama,2 and David Y. Chen1

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Tony Yao,¹ Rita E. Chen,¹ Melissa Yamada,¹ J. Russell Moore,¹ Marissa Jimenez,¹ Tammy Huang,² Lynn Cornelius,¹ George Ansstas,¹ Naresha Saligrama,² and David Y. Chen¹