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ResearchIn-Press PreviewGastroenterologyImmunologyOncology
Open Access | 
10.1172/JCI199516
A CD138+ tumor-associated macrophage-Siglec-F+ neutrophil feedforward loop promotes immune evasion in pancreatic cancer
Chao Wang,1 Qi Zhang,2 Jinyan Huang,3 Fangyu Lin,2 Danyang Zhao,3 Youling Mu,3 Junshuo Tong,3 Jinping Li,3 Yingjiqiong Liang,3 Tao Zeng,3 Fukang Shi,2 Hang Shen,2 Tingting Lu,5 and Tingbo Liang2
1Department of Hepatobiliary and Pancreatic Surgery, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
2Department of Hepatobiliary and Pancreatic Surgery, Zhejiang University School of Medicine, Hangzhou, China
3Zhejiang Provincial Key Laboratory of Pancreatic Disease, Zhejiang University School of Medicine, Hangzhou, China
4Zhejiang Provincial Key Laboratory of Pancreatic Disease, Zhejiang University School of Medicine, HangZhou, China
5Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disor, Shanghai Jiao Tong University, Shanghai, China
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1Department of Hepatobiliary and Pancreatic Surgery, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
2Department of Hepatobiliary and Pancreatic Surgery, Zhejiang University School of Medicine, Hangzhou, China
3Zhejiang Provincial Key Laboratory of Pancreatic Disease, Zhejiang University School of Medicine, Hangzhou, China
4Zhejiang Provincial Key Laboratory of Pancreatic Disease, Zhejiang University School of Medicine, HangZhou, China
5Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disor, Shanghai Jiao Tong University, Shanghai, China
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1Department of Hepatobiliary and Pancreatic Surgery, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
2Department of Hepatobiliary and Pancreatic Surgery, Zhejiang University School of Medicine, Hangzhou, China
3Zhejiang Provincial Key Laboratory of Pancreatic Disease, Zhejiang University School of Medicine, Hangzhou, China
4Zhejiang Provincial Key Laboratory of Pancreatic Disease, Zhejiang University School of Medicine, HangZhou, China
5Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disor, Shanghai Jiao Tong University, Shanghai, China
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Huang, J.
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1Department of Hepatobiliary and Pancreatic Surgery, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
2Department of Hepatobiliary and Pancreatic Surgery, Zhejiang University School of Medicine, Hangzhou, China
3Zhejiang Provincial Key Laboratory of Pancreatic Disease, Zhejiang University School of Medicine, Hangzhou, China
4Zhejiang Provincial Key Laboratory of Pancreatic Disease, Zhejiang University School of Medicine, HangZhou, China
5Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disor, Shanghai Jiao Tong University, Shanghai, China
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1Department of Hepatobiliary and Pancreatic Surgery, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
2Department of Hepatobiliary and Pancreatic Surgery, Zhejiang University School of Medicine, Hangzhou, China
3Zhejiang Provincial Key Laboratory of Pancreatic Disease, Zhejiang University School of Medicine, Hangzhou, China
4Zhejiang Provincial Key Laboratory of Pancreatic Disease, Zhejiang University School of Medicine, HangZhou, China
5Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disor, Shanghai Jiao Tong University, Shanghai, China
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Zhao, D.
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1Department of Hepatobiliary and Pancreatic Surgery, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
2Department of Hepatobiliary and Pancreatic Surgery, Zhejiang University School of Medicine, Hangzhou, China
3Zhejiang Provincial Key Laboratory of Pancreatic Disease, Zhejiang University School of Medicine, Hangzhou, China
4Zhejiang Provincial Key Laboratory of Pancreatic Disease, Zhejiang University School of Medicine, HangZhou, China
5Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disor, Shanghai Jiao Tong University, Shanghai, China
Find articles by Mu, Y. in: PubMed | Google Scholar
1Department of Hepatobiliary and Pancreatic Surgery, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
2Department of Hepatobiliary and Pancreatic Surgery, Zhejiang University School of Medicine, Hangzhou, China
3Zhejiang Provincial Key Laboratory of Pancreatic Disease, Zhejiang University School of Medicine, Hangzhou, China
4Zhejiang Provincial Key Laboratory of Pancreatic Disease, Zhejiang University School of Medicine, HangZhou, China
5Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disor, Shanghai Jiao Tong University, Shanghai, China
Find articles by Tong, J. in: PubMed | Google Scholar
1Department of Hepatobiliary and Pancreatic Surgery, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
2Department of Hepatobiliary and Pancreatic Surgery, Zhejiang University School of Medicine, Hangzhou, China
3Zhejiang Provincial Key Laboratory of Pancreatic Disease, Zhejiang University School of Medicine, Hangzhou, China
4Zhejiang Provincial Key Laboratory of Pancreatic Disease, Zhejiang University School of Medicine, HangZhou, China
5Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disor, Shanghai Jiao Tong University, Shanghai, China
Find articles by Li, J. in: PubMed | Google Scholar
1Department of Hepatobiliary and Pancreatic Surgery, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
2Department of Hepatobiliary and Pancreatic Surgery, Zhejiang University School of Medicine, Hangzhou, China
3Zhejiang Provincial Key Laboratory of Pancreatic Disease, Zhejiang University School of Medicine, Hangzhou, China
4Zhejiang Provincial Key Laboratory of Pancreatic Disease, Zhejiang University School of Medicine, HangZhou, China
5Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disor, Shanghai Jiao Tong University, Shanghai, China
Find articles by Liang, Y. in: PubMed | Google Scholar
1Department of Hepatobiliary and Pancreatic Surgery, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
2Department of Hepatobiliary and Pancreatic Surgery, Zhejiang University School of Medicine, Hangzhou, China
3Zhejiang Provincial Key Laboratory of Pancreatic Disease, Zhejiang University School of Medicine, Hangzhou, China
4Zhejiang Provincial Key Laboratory of Pancreatic Disease, Zhejiang University School of Medicine, HangZhou, China
5Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disor, Shanghai Jiao Tong University, Shanghai, China
Find articles by Zeng, T. in: PubMed | Google Scholar
1Department of Hepatobiliary and Pancreatic Surgery, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
2Department of Hepatobiliary and Pancreatic Surgery, Zhejiang University School of Medicine, Hangzhou, China
3Zhejiang Provincial Key Laboratory of Pancreatic Disease, Zhejiang University School of Medicine, Hangzhou, China
4Zhejiang Provincial Key Laboratory of Pancreatic Disease, Zhejiang University School of Medicine, HangZhou, China
5Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disor, Shanghai Jiao Tong University, Shanghai, China
Find articles by Shi, F. in: PubMed | Google Scholar
1Department of Hepatobiliary and Pancreatic Surgery, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
2Department of Hepatobiliary and Pancreatic Surgery, Zhejiang University School of Medicine, Hangzhou, China
3Zhejiang Provincial Key Laboratory of Pancreatic Disease, Zhejiang University School of Medicine, Hangzhou, China
4Zhejiang Provincial Key Laboratory of Pancreatic Disease, Zhejiang University School of Medicine, HangZhou, China
5Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disor, Shanghai Jiao Tong University, Shanghai, China
Find articles by Shen, H. in: PubMed | Google Scholar
1Department of Hepatobiliary and Pancreatic Surgery, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
2Department of Hepatobiliary and Pancreatic Surgery, Zhejiang University School of Medicine, Hangzhou, China
3Zhejiang Provincial Key Laboratory of Pancreatic Disease, Zhejiang University School of Medicine, Hangzhou, China
4Zhejiang Provincial Key Laboratory of Pancreatic Disease, Zhejiang University School of Medicine, HangZhou, China
5Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disor, Shanghai Jiao Tong University, Shanghai, China
Find articles by Lu, T. in: PubMed | Google Scholar
1Department of Hepatobiliary and Pancreatic Surgery, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
2Department of Hepatobiliary and Pancreatic Surgery, Zhejiang University School of Medicine, Hangzhou, China
3Zhejiang Provincial Key Laboratory of Pancreatic Disease, Zhejiang University School of Medicine, Hangzhou, China
4Zhejiang Provincial Key Laboratory of Pancreatic Disease, Zhejiang University School of Medicine, HangZhou, China
5Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disor, Shanghai Jiao Tong University, Shanghai, China
Find articles by Liang, T. in: PubMed | Google Scholar
Published March 12, 2026 - More info
Copyright © 2026, Wang et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Copyright © 2026 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)