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ResearchIn-Press PreviewCell biologyImmunology
Open Access | 
10.1172/JCI199108
DYRK1A enhances antitumor immunity in type 1 conventional dendritic cells via mTORC1 activation
Hongjiao Wang,1 He Jiang,1 Songlin He,2 Songwen Ren,1 Haiwen Li,3 Wangnan Liu,1 Chunyun Zhou,4 Pan Zhu,1 Keren Chen,1 Weijia Cao,1 Yan Qin,3 Dan Du,5 Nengming Xiao,1 Hongling Huang,1 Chun-Jung Ko,6 Yiming Zheng,1 Bo Wang,1 Qiang Zou,7 Jian-Hong Shi,3 Xun Li,2 and Zuliang Jie1
1Department of Oncology, School of Life Sciences, Xiamen University, Xiamen, China
2Department of Laboratory Medicine, School of Medicine, Xiamen University, Xiamen, China
3Central Laboratory, Hebei Collaborative Innovation Center of Tumor Microeco, Clinical Medical College, Hebei University, Hebei, China
4School of Public Health, Xiamen University, Xiamen, China
5Department of Stomatology, Cancer Research Center, School of Medicine, Xiamen University, Xiamen, China
6Graduate Institute of Immunology, College of Medicine, National Taiwan University, Taipei, Taiwan
7Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Find articles by Wang, H. in: PubMed | Google Scholar
1Department of Oncology, School of Life Sciences, Xiamen University, Xiamen, China
2Department of Laboratory Medicine, School of Medicine, Xiamen University, Xiamen, China
3Central Laboratory, Hebei Collaborative Innovation Center of Tumor Microeco, Clinical Medical College, Hebei University, Hebei, China
4School of Public Health, Xiamen University, Xiamen, China
5Department of Stomatology, Cancer Research Center, School of Medicine, Xiamen University, Xiamen, China
6Graduate Institute of Immunology, College of Medicine, National Taiwan University, Taipei, Taiwan
7Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Find articles by Jiang, H. in: PubMed | Google Scholar
1Department of Oncology, School of Life Sciences, Xiamen University, Xiamen, China
2Department of Laboratory Medicine, School of Medicine, Xiamen University, Xiamen, China
3Central Laboratory, Hebei Collaborative Innovation Center of Tumor Microeco, Clinical Medical College, Hebei University, Hebei, China
4School of Public Health, Xiamen University, Xiamen, China
5Department of Stomatology, Cancer Research Center, School of Medicine, Xiamen University, Xiamen, China
6Graduate Institute of Immunology, College of Medicine, National Taiwan University, Taipei, Taiwan
7Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Find articles by He, S. in: PubMed | Google Scholar
1Department of Oncology, School of Life Sciences, Xiamen University, Xiamen, China
2Department of Laboratory Medicine, School of Medicine, Xiamen University, Xiamen, China
3Central Laboratory, Hebei Collaborative Innovation Center of Tumor Microeco, Clinical Medical College, Hebei University, Hebei, China
4School of Public Health, Xiamen University, Xiamen, China
5Department of Stomatology, Cancer Research Center, School of Medicine, Xiamen University, Xiamen, China
6Graduate Institute of Immunology, College of Medicine, National Taiwan University, Taipei, Taiwan
7Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Find articles by Ren, S. in: PubMed | Google Scholar
1Department of Oncology, School of Life Sciences, Xiamen University, Xiamen, China
2Department of Laboratory Medicine, School of Medicine, Xiamen University, Xiamen, China
3Central Laboratory, Hebei Collaborative Innovation Center of Tumor Microeco, Clinical Medical College, Hebei University, Hebei, China
4School of Public Health, Xiamen University, Xiamen, China
5Department of Stomatology, Cancer Research Center, School of Medicine, Xiamen University, Xiamen, China
6Graduate Institute of Immunology, College of Medicine, National Taiwan University, Taipei, Taiwan
7Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Find articles by Li, H. in: PubMed | Google Scholar
1Department of Oncology, School of Life Sciences, Xiamen University, Xiamen, China
2Department of Laboratory Medicine, School of Medicine, Xiamen University, Xiamen, China
3Central Laboratory, Hebei Collaborative Innovation Center of Tumor Microeco, Clinical Medical College, Hebei University, Hebei, China
4School of Public Health, Xiamen University, Xiamen, China
5Department of Stomatology, Cancer Research Center, School of Medicine, Xiamen University, Xiamen, China
6Graduate Institute of Immunology, College of Medicine, National Taiwan University, Taipei, Taiwan
7Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Find articles by Liu, W. in: PubMed | Google Scholar
1Department of Oncology, School of Life Sciences, Xiamen University, Xiamen, China
2Department of Laboratory Medicine, School of Medicine, Xiamen University, Xiamen, China
3Central Laboratory, Hebei Collaborative Innovation Center of Tumor Microeco, Clinical Medical College, Hebei University, Hebei, China
4School of Public Health, Xiamen University, Xiamen, China
5Department of Stomatology, Cancer Research Center, School of Medicine, Xiamen University, Xiamen, China
6Graduate Institute of Immunology, College of Medicine, National Taiwan University, Taipei, Taiwan
7Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Find articles by Zhou, C. in: PubMed | Google Scholar
1Department of Oncology, School of Life Sciences, Xiamen University, Xiamen, China
2Department of Laboratory Medicine, School of Medicine, Xiamen University, Xiamen, China
3Central Laboratory, Hebei Collaborative Innovation Center of Tumor Microeco, Clinical Medical College, Hebei University, Hebei, China
4School of Public Health, Xiamen University, Xiamen, China
5Department of Stomatology, Cancer Research Center, School of Medicine, Xiamen University, Xiamen, China
6Graduate Institute of Immunology, College of Medicine, National Taiwan University, Taipei, Taiwan
7Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Find articles by Zhu, P. in: PubMed | Google Scholar
1Department of Oncology, School of Life Sciences, Xiamen University, Xiamen, China
2Department of Laboratory Medicine, School of Medicine, Xiamen University, Xiamen, China
3Central Laboratory, Hebei Collaborative Innovation Center of Tumor Microeco, Clinical Medical College, Hebei University, Hebei, China
4School of Public Health, Xiamen University, Xiamen, China
5Department of Stomatology, Cancer Research Center, School of Medicine, Xiamen University, Xiamen, China
6Graduate Institute of Immunology, College of Medicine, National Taiwan University, Taipei, Taiwan
7Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Find articles by Chen, K. in: PubMed | Google Scholar
1Department of Oncology, School of Life Sciences, Xiamen University, Xiamen, China
2Department of Laboratory Medicine, School of Medicine, Xiamen University, Xiamen, China
3Central Laboratory, Hebei Collaborative Innovation Center of Tumor Microeco, Clinical Medical College, Hebei University, Hebei, China
4School of Public Health, Xiamen University, Xiamen, China
5Department of Stomatology, Cancer Research Center, School of Medicine, Xiamen University, Xiamen, China
6Graduate Institute of Immunology, College of Medicine, National Taiwan University, Taipei, Taiwan
7Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Find articles by Cao, W. in: PubMed | Google Scholar
1Department of Oncology, School of Life Sciences, Xiamen University, Xiamen, China
2Department of Laboratory Medicine, School of Medicine, Xiamen University, Xiamen, China
3Central Laboratory, Hebei Collaborative Innovation Center of Tumor Microeco, Clinical Medical College, Hebei University, Hebei, China
4School of Public Health, Xiamen University, Xiamen, China
5Department of Stomatology, Cancer Research Center, School of Medicine, Xiamen University, Xiamen, China
6Graduate Institute of Immunology, College of Medicine, National Taiwan University, Taipei, Taiwan
7Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Find articles by Qin, Y. in: PubMed | Google Scholar
1Department of Oncology, School of Life Sciences, Xiamen University, Xiamen, China
2Department of Laboratory Medicine, School of Medicine, Xiamen University, Xiamen, China
3Central Laboratory, Hebei Collaborative Innovation Center of Tumor Microeco, Clinical Medical College, Hebei University, Hebei, China
4School of Public Health, Xiamen University, Xiamen, China
5Department of Stomatology, Cancer Research Center, School of Medicine, Xiamen University, Xiamen, China
6Graduate Institute of Immunology, College of Medicine, National Taiwan University, Taipei, Taiwan
7Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Find articles by Du, D. in: PubMed | Google Scholar
1Department of Oncology, School of Life Sciences, Xiamen University, Xiamen, China
2Department of Laboratory Medicine, School of Medicine, Xiamen University, Xiamen, China
3Central Laboratory, Hebei Collaborative Innovation Center of Tumor Microeco, Clinical Medical College, Hebei University, Hebei, China
4School of Public Health, Xiamen University, Xiamen, China
5Department of Stomatology, Cancer Research Center, School of Medicine, Xiamen University, Xiamen, China
6Graduate Institute of Immunology, College of Medicine, National Taiwan University, Taipei, Taiwan
7Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Find articles by Xiao, N. in: PubMed | Google Scholar
1Department of Oncology, School of Life Sciences, Xiamen University, Xiamen, China
2Department of Laboratory Medicine, School of Medicine, Xiamen University, Xiamen, China
3Central Laboratory, Hebei Collaborative Innovation Center of Tumor Microeco, Clinical Medical College, Hebei University, Hebei, China
4School of Public Health, Xiamen University, Xiamen, China
5Department of Stomatology, Cancer Research Center, School of Medicine, Xiamen University, Xiamen, China
6Graduate Institute of Immunology, College of Medicine, National Taiwan University, Taipei, Taiwan
7Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Find articles by Huang, H. in: PubMed | Google Scholar
1Department of Oncology, School of Life Sciences, Xiamen University, Xiamen, China
2Department of Laboratory Medicine, School of Medicine, Xiamen University, Xiamen, China
3Central Laboratory, Hebei Collaborative Innovation Center of Tumor Microeco, Clinical Medical College, Hebei University, Hebei, China
4School of Public Health, Xiamen University, Xiamen, China
5Department of Stomatology, Cancer Research Center, School of Medicine, Xiamen University, Xiamen, China
6Graduate Institute of Immunology, College of Medicine, National Taiwan University, Taipei, Taiwan
7Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Ko, C.
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1Department of Oncology, School of Life Sciences, Xiamen University, Xiamen, China
2Department of Laboratory Medicine, School of Medicine, Xiamen University, Xiamen, China
3Central Laboratory, Hebei Collaborative Innovation Center of Tumor Microeco, Clinical Medical College, Hebei University, Hebei, China
4School of Public Health, Xiamen University, Xiamen, China
5Department of Stomatology, Cancer Research Center, School of Medicine, Xiamen University, Xiamen, China
6Graduate Institute of Immunology, College of Medicine, National Taiwan University, Taipei, Taiwan
7Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Find articles by Zheng, Y. in: PubMed | Google Scholar
1Department of Oncology, School of Life Sciences, Xiamen University, Xiamen, China
2Department of Laboratory Medicine, School of Medicine, Xiamen University, Xiamen, China
3Central Laboratory, Hebei Collaborative Innovation Center of Tumor Microeco, Clinical Medical College, Hebei University, Hebei, China
4School of Public Health, Xiamen University, Xiamen, China
5Department of Stomatology, Cancer Research Center, School of Medicine, Xiamen University, Xiamen, China
6Graduate Institute of Immunology, College of Medicine, National Taiwan University, Taipei, Taiwan
7Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Find articles by Wang, B. in: PubMed | Google Scholar
1Department of Oncology, School of Life Sciences, Xiamen University, Xiamen, China
2Department of Laboratory Medicine, School of Medicine, Xiamen University, Xiamen, China
3Central Laboratory, Hebei Collaborative Innovation Center of Tumor Microeco, Clinical Medical College, Hebei University, Hebei, China
4School of Public Health, Xiamen University, Xiamen, China
5Department of Stomatology, Cancer Research Center, School of Medicine, Xiamen University, Xiamen, China
6Graduate Institute of Immunology, College of Medicine, National Taiwan University, Taipei, Taiwan
7Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Find articles by Zou, Q. in: PubMed | Google Scholar
1Department of Oncology, School of Life Sciences, Xiamen University, Xiamen, China
2Department of Laboratory Medicine, School of Medicine, Xiamen University, Xiamen, China
3Central Laboratory, Hebei Collaborative Innovation Center of Tumor Microeco, Clinical Medical College, Hebei University, Hebei, China
4School of Public Health, Xiamen University, Xiamen, China
5Department of Stomatology, Cancer Research Center, School of Medicine, Xiamen University, Xiamen, China
6Graduate Institute of Immunology, College of Medicine, National Taiwan University, Taipei, Taiwan
7Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Shi, J.
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1Department of Oncology, School of Life Sciences, Xiamen University, Xiamen, China
2Department of Laboratory Medicine, School of Medicine, Xiamen University, Xiamen, China
3Central Laboratory, Hebei Collaborative Innovation Center of Tumor Microeco, Clinical Medical College, Hebei University, Hebei, China
4School of Public Health, Xiamen University, Xiamen, China
5Department of Stomatology, Cancer Research Center, School of Medicine, Xiamen University, Xiamen, China
6Graduate Institute of Immunology, College of Medicine, National Taiwan University, Taipei, Taiwan
7Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Find articles by Li, X. in: PubMed | Google Scholar
1Department of Oncology, School of Life Sciences, Xiamen University, Xiamen, China
2Department of Laboratory Medicine, School of Medicine, Xiamen University, Xiamen, China
3Central Laboratory, Hebei Collaborative Innovation Center of Tumor Microeco, Clinical Medical College, Hebei University, Hebei, China
4School of Public Health, Xiamen University, Xiamen, China
5Department of Stomatology, Cancer Research Center, School of Medicine, Xiamen University, Xiamen, China
6Graduate Institute of Immunology, College of Medicine, National Taiwan University, Taipei, Taiwan
7Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Published April 23, 2026 - More info
Copyright © 2026, Wang et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Copyright © 2026 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)