(A and B) Univariable (A) and multivariable (B) regression model between indicated variables and log₂(NLR). N = 8,095. Box-and-whisker plots show the regression coefficient with 95% confidence interval. (C) Kaplan-Meier curves following ICI treatment for NHW (N = 1,135) and NHB patients (N = 91) from MSKCC. (D) Significance determined by log-rank test as function of NLR threshold values in patients from MSKCC. Shaded region indicates standard deviation from cross-validation. NHW N = 1,135, NHB N = 91, Asian N = 96. (E–J) Kaplan-Meier curves following ICI treatments in patients from CCF with (E) lung cancer, NHW N = 2550, NHB N = 49; (F) breast cancer, NHW N = 352, NHB N = 102; (G) kidney cancer, NHW N = 508, NHB N = 46, (H) liver cancer, NHW N = 348, NHB N = 57; (I) cervical cancer, NHW N = 109, NHB N = 21; and (J) head and neck cancers, NHW N = 408, NHB N = 71. For all Kaplan-Meier curves, log-rank P values are shown with values split at upper tertile of cohort. HR, hazard ratio.