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Research LetterIn-Press PreviewOncologyPublic Health
Open Access | 
10.1172/JCI198948
Neutrophil to lymphocyte ratio varies in magnitude and biomarker utility based on patient demographics
William Ang,1 Travis D. Kerr,1 Ananya Kodiboyena,2 Cristina Valero,3 Joris L. Vos,3 Vladimir Makarov,1 Alex A. Adjei,4 Luc G.T. Morris,3 Stephanie L. Schmit,5 Natalie L. Silver,6 Sujata Patil,2 and Daniel J. McGrail1
1Center for Immunotherapy and Precision Immuno-Oncology, Cleveland Clinic, Cleveland, United States of America
2Quantitative Health Sciences, Cleveland Clinic, Cleveland, United States of America
3Head and Neck Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, United States of America
4Taussig Cancer Institute, Cleveland Clinic, Cleveland, United States of America
5Genomic Medicine Institute, Cleveland Clinic, Cleveland, United States of America
6Head and Neck Institute, Cleveland Clinic, Cleveland, United States of America
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1Center for Immunotherapy and Precision Immuno-Oncology, Cleveland Clinic, Cleveland, United States of America
2Quantitative Health Sciences, Cleveland Clinic, Cleveland, United States of America
3Head and Neck Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, United States of America
4Taussig Cancer Institute, Cleveland Clinic, Cleveland, United States of America
5Genomic Medicine Institute, Cleveland Clinic, Cleveland, United States of America
6Head and Neck Institute, Cleveland Clinic, Cleveland, United States of America
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1Center for Immunotherapy and Precision Immuno-Oncology, Cleveland Clinic, Cleveland, United States of America
2Quantitative Health Sciences, Cleveland Clinic, Cleveland, United States of America
3Head and Neck Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, United States of America
4Taussig Cancer Institute, Cleveland Clinic, Cleveland, United States of America
5Genomic Medicine Institute, Cleveland Clinic, Cleveland, United States of America
6Head and Neck Institute, Cleveland Clinic, Cleveland, United States of America
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1Center for Immunotherapy and Precision Immuno-Oncology, Cleveland Clinic, Cleveland, United States of America
2Quantitative Health Sciences, Cleveland Clinic, Cleveland, United States of America
3Head and Neck Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, United States of America
4Taussig Cancer Institute, Cleveland Clinic, Cleveland, United States of America
5Genomic Medicine Institute, Cleveland Clinic, Cleveland, United States of America
6Head and Neck Institute, Cleveland Clinic, Cleveland, United States of America
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Valero, C.
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1Center for Immunotherapy and Precision Immuno-Oncology, Cleveland Clinic, Cleveland, United States of America
2Quantitative Health Sciences, Cleveland Clinic, Cleveland, United States of America
3Head and Neck Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, United States of America
4Taussig Cancer Institute, Cleveland Clinic, Cleveland, United States of America
5Genomic Medicine Institute, Cleveland Clinic, Cleveland, United States of America
6Head and Neck Institute, Cleveland Clinic, Cleveland, United States of America
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Vos, J.
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1Center for Immunotherapy and Precision Immuno-Oncology, Cleveland Clinic, Cleveland, United States of America
2Quantitative Health Sciences, Cleveland Clinic, Cleveland, United States of America
3Head and Neck Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, United States of America
4Taussig Cancer Institute, Cleveland Clinic, Cleveland, United States of America
5Genomic Medicine Institute, Cleveland Clinic, Cleveland, United States of America
6Head and Neck Institute, Cleveland Clinic, Cleveland, United States of America
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1Center for Immunotherapy and Precision Immuno-Oncology, Cleveland Clinic, Cleveland, United States of America
2Quantitative Health Sciences, Cleveland Clinic, Cleveland, United States of America
3Head and Neck Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, United States of America
4Taussig Cancer Institute, Cleveland Clinic, Cleveland, United States of America
5Genomic Medicine Institute, Cleveland Clinic, Cleveland, United States of America
6Head and Neck Institute, Cleveland Clinic, Cleveland, United States of America
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1Center for Immunotherapy and Precision Immuno-Oncology, Cleveland Clinic, Cleveland, United States of America
2Quantitative Health Sciences, Cleveland Clinic, Cleveland, United States of America
3Head and Neck Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, United States of America
4Taussig Cancer Institute, Cleveland Clinic, Cleveland, United States of America
5Genomic Medicine Institute, Cleveland Clinic, Cleveland, United States of America
6Head and Neck Institute, Cleveland Clinic, Cleveland, United States of America
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Morris, L.
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1Center for Immunotherapy and Precision Immuno-Oncology, Cleveland Clinic, Cleveland, United States of America
2Quantitative Health Sciences, Cleveland Clinic, Cleveland, United States of America
3Head and Neck Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, United States of America
4Taussig Cancer Institute, Cleveland Clinic, Cleveland, United States of America
5Genomic Medicine Institute, Cleveland Clinic, Cleveland, United States of America
6Head and Neck Institute, Cleveland Clinic, Cleveland, United States of America
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1Center for Immunotherapy and Precision Immuno-Oncology, Cleveland Clinic, Cleveland, United States of America
2Quantitative Health Sciences, Cleveland Clinic, Cleveland, United States of America
3Head and Neck Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, United States of America
4Taussig Cancer Institute, Cleveland Clinic, Cleveland, United States of America
5Genomic Medicine Institute, Cleveland Clinic, Cleveland, United States of America
6Head and Neck Institute, Cleveland Clinic, Cleveland, United States of America
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1Center for Immunotherapy and Precision Immuno-Oncology, Cleveland Clinic, Cleveland, United States of America
2Quantitative Health Sciences, Cleveland Clinic, Cleveland, United States of America
3Head and Neck Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, United States of America
4Taussig Cancer Institute, Cleveland Clinic, Cleveland, United States of America
5Genomic Medicine Institute, Cleveland Clinic, Cleveland, United States of America
6Head and Neck Institute, Cleveland Clinic, Cleveland, United States of America
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1Center for Immunotherapy and Precision Immuno-Oncology, Cleveland Clinic, Cleveland, United States of America
2Quantitative Health Sciences, Cleveland Clinic, Cleveland, United States of America
3Head and Neck Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, United States of America
4Taussig Cancer Institute, Cleveland Clinic, Cleveland, United States of America
5Genomic Medicine Institute, Cleveland Clinic, Cleveland, United States of America
6Head and Neck Institute, Cleveland Clinic, Cleveland, United States of America
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McGrail, D.
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Published November 11, 2025 - More info
Copyright © 2025, Ang et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)