F18-FDG PET imaging as a diagnostic tool for immune checkpoint inhibitor–associated acute kidney injury
Shruti Gupta, … , Ilya Glezerman, David E. Leaf
Shruti Gupta, … , Ilya Glezerman, David E. Leaf
Published August 8, 2024
Citation Information: J Clin Invest. 2024;134(18):e182275. https://doi.org/10.1172/JCI182275.
View: Text | PDF
Research Letter Nephrology Oncology

F18-FDG PET imaging as a diagnostic tool for immune checkpoint inhibitor–associated acute kidney injury

Abstract

Authors

Shruti Gupta, Olivia Green-Lingren, Sudhir Bhimaniya, Aleksandra Krokhmal, Heather Jacene, Marlies Ostermann, Sugama Chicklore, Ben Sprangers, Christophe M. Deroose, Sandra M. Herrmann, Sophia L. Wells, Sarah A. Kaunfer, Jessica L. Ortega, Clara García-Carro, Michael Bold, Kevin L. Chen, Meghan E. Sise, Pedram Heidari, Wai Lun Will Pak, Meghan D. Lee, Pazit Beckerman, Yael Eshet, Raymond K. Hsu, Miguel Hernandez Pampaloni, Arash Rashidi, Norbert Avril, Vicki Donley, Zain Mithani, Russ Kuker, Muhammad O Awiwi, Mindy X. Wang, Sujal I. Shah, Michael D. Weintraub, Heiko Schoder, Raad B. Chowdhury, Harish Seethapathy, Kerry L. Reynolds, Maria Jose Soler, Ala Abudayyeh, Ilya Glezerman, David E. Leaf

×

Figure 1

F18-FDG PET-CT and ICI-AKI.

Options: View larger image (or click on image) Download as PowerPoint
F18-FDG PET-CT and ICI-AKI. (A) Representative F18-FDG PET-CT images at ...
(A) Representative F18-FDG PET-CT images at baseline (top panels) and at the time of ICI-AKI (lower panels). (B) Percentage change in SUVmean from baseline to the time of AKI among patients with ICI-AKI (red), AKI from other causes (blue), and patients receiving ICI therapy without AKI (green). Biopsy-proven patients are represented by squares, and clinically adjudicated patients with circles. (C) ROC curve of percentage change in SUVmean for differentiation of ICI-AKI from AKI from other causes.