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Role for integrin-linked kinase in mediating tubular epithelial to mesenchymal transition and renal interstitial fibrogenesis
Yingjian Li, … , Chuanyue Wu, Youhua Liu
Yingjian Li, … , Chuanyue Wu, Youhua Liu
Published February 1, 2004
Citation Information: J Clin Invest. 2004;113(3):491-491. https://doi.org/10.1172/JCI17913C1.
View: Text | PDF | Amended Article
Corrigendum Nephrology

Role for integrin-linked kinase in mediating tubular epithelial to mesenchymal transition and renal interstitial fibrogenesis

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Abstract

Authors

Yingjian Li, Junwei Yang, Chunsun Dai, Chuanyue Wu, Youhua Liu

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Figure 1

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TGF-β1 induces ILK expression in renal tubular epithelial cells.
       ...
TGF-β1 induces ILK expression in renal tubular epithelial cells. (a–d) Western blot analyses show that TGF-β1 induced ILK protein expression in a time- and dose-dependent manner. HKC cells were incubated with either the same concentration of TGF-β1 (2 ng/ml) for various periods of time as indicated (a and c) or increasing amounts of TGF-β1 for 24 hours (b and d). Cell lysates were immunoblotted with Ab’s against ILK and actin, respectively. (a and b) Representative Western blots. (c and d) Graphic presentation of relative ILK abundance (fold induction) normalized to actin. Data are presented as mean ± SEM of three independent experiments. (e and f) Immunofluorescence staining shows the localization of ILK in control (e) or TGF-β1–treated HKC cells (f). Arrowheads indicate positive ILK staining. Scale bar: 5 μm.

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