Restoration of LDL receptor function in cells from patients with autosomal recessive hypercholesterolemia by retroviral expression of ARH1
Emily R. Eden, … , Rossitza P. Naoumova, Anne K. Soutar
Emily R. Eden, … , Rossitza P. Naoumova, Anne K. Soutar
Published December 1, 2002
Citation Information: J Clin Invest. 2002;110(11):1695-1702. https://doi.org/10.1172/JCI16445.
View: Text | PDF
Article Cardiology

Restoration of LDL receptor function in cells from patients with autosomal recessive hypercholesterolemia by retroviral expression of ARH1

Abstract

Research Article

Authors

Emily R. Eden, Dilipkumar D. Patel, Xi-Ming Sun, Jemima J. Burden, Michael Themis, Matthew Edwards, Philip Lee, Clare Neuwirth, Rossitza P. Naoumova, Anne K. Soutar

×

Figure 3

Options: View larger image (or click on image) Download as PowerPoint
Identification of a partial deletion of ARH1 in family 3. (a) Diagram sh...
Identification of a partial deletion of ARH1 in family 3. (a) Diagram showing the approximate size of the ARH1 DNA probes used for fluorescent in situ hybridization (FISH). The vertical black bars represent the nine exons of ARH1. (b) Metaphase chromosomes from individual FH3.1 were hybridized with either DIG-labeled ARH1 DNA probe 1 or probe 2 as indicated (detected with FITC-labeled anti-DIG Ab; small filled arrows) and biotin-labeled chromosome 1–specific α-satellite probe DNA (detected with Cy3-labeled anti-biotin Ab; large open arrows).